Setting description

treatments equally effective across the biomarker signatures

Simulations setting

PFS distributions


Treatment effects

By subgroup:

subtype var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1


By signature:

signature var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
all param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TP53- & AR- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TP53+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
DRD+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 11 4 1 1
TP53- & AR- 50 44 24 22
TP53+ 14 4 3 2
DRD+ 3 1 2 2
TEfus+ 3 1 4 2
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.022 0.008 0.002 0.002
TP53- & AR- 0.100 0.088 0.048 0.044
TP53+ 0.028 0.008 0.006 0.004
DRD+ 0.006 0.002 0.004 0.004
TEfus+ 0.006 0.002 0.008 0.004
futility (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 11 1 1 2
TP53- & AR- 161 116 128 119
TP53+ 38 33 32 31
DRD+ 16 18 15 25
TEfus+ 29 24 17 26
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.022 0.002 0.002 0.004
TP53- & AR- 0.322 0.232 0.256 0.238
TP53+ 0.076 0.066 0.064 0.062
DRD+ 0.032 0.036 0.030 0.050
TEfus+ 0.058 0.048 0.034 0.052
max sample size (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 0 0 0
TP53- & AR- 17 13 12 18
TP53+ 7 12 6 8
DRD+ 0 0 0 0
TEfus+ 0 2 1 0
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.000 0.000 0.000
TP53- & AR- 0.034 0.026 0.024 0.036
TP53+ 0.014 0.024 0.012 0.016
DRD+ 0.000 0.000 0.000 0.000
TEfus+ 0.000 0.004 0.002 0.000


Errors & power

The overall error was 0.344.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.152             0.102             0.066             0.058

The overall power was .
The corresponding power separate for the different treatments were:

NULL

Median results at the end of the trial

By signature:
signature var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
all graduation 0 11 4 1 1
futility 0 11 1 1 2
max_n 0 0 0 0 0
n 420 (386, 456) 182 (119, 249) 196 (133, 252) 186 (130, 258) 188 (132, 255)
n_unique 385 (354, 418) 166 (108, 231) 179 (120, 234) 170 (117, 237) 170 (118, 235)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 4 (3, 6) 5 (4, 10) 6 (6, 7) 7 (7, 15)
post_p NA (NA, NA) 0.48 (0.08, 0.87) 0.51 (0.09, 0.89) 0.45 (0.1, 0.87) 0.47 (0.08, 0.89)
rate 0.112 (0.104, 0.12) 0.113 (0.101, 0.127) 0.112 (0.101, 0.127) 0.113 (0.102, 0.126) 0.113 (0.102, 0.126)
TP53- & AR- graduation 0 50 44 24 22
futility 0 161 116 128 119
max_n 0 17 13 12 18
n 176 (152, 199) 63 (26, 128) 65 (27, 122) 70 (29, 130) 70 (29, 128)
n_unique 162 (138, 185) 58 (25, 121) 59 (24, 114) 64 (26, 122) 64 (27, 120)
time_trial 36 (36, 36) 36 (9, 36) 36 (17, 36) 36 (18, 36) 36 (19, 36)
time_stop NA (NA, NA) 13 (7, 31) 20 (11, 32) 21 (12, 33) 21 (13, 32)
post_p NA (NA, NA) 0.45 (0.11, 0.86) 0.47 (0.08, 0.91) 0.45 (0.1, 0.88) 0.45 (0.1, 0.88)
rate 0.112 (0.1, 0.124) 0.115 (0.098, 0.141) 0.114 (0.094, 0.144) 0.115 (0.097, 0.143) 0.114 (0.098, 0.141)
TP53+ graduation 0 14 4 3 2
futility 0 38 33 32 31
max_n 0 7 12 6 8
n 186 (163, 207) 86 (39, 123) 91 (55, 131) 86 (52, 123) 84 (54, 122)
n_unique 169 (148, 188) 79 (37, 113) 82 (50, 120) 78 (47, 113) 76 (48, 110)
time_trial 36 (36, 36) 36 (30, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 18 (8, 28) 17 (10, 29) 21 (12, 34) 22 (12, 33)
post_p NA (NA, NA) 0.47 (0.1, 0.9) 0.5 (0.1, 0.89) 0.48 (0.09, 0.87) 0.48 (0.09, 0.89)
rate 0.111 (0.101, 0.126) 0.113 (0.096, 0.133) 0.113 (0.098, 0.133) 0.113 (0.098, 0.137) 0.114 (0.097, 0.134)
DRD+ graduation 0 3 1 2 2
futility 0 16 18 15 25
max_n 0 0 0 0 0
n 114 (98, 129) 45 (25, 66) 49 (30, 68) 62 (43, 85) 62 (42, 85)
n_unique 103 (89, 119) 41 (23, 60) 44 (27, 62) 56 (38, 78) 56 (36, 77)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 30 (19, 34) 28 (17, 32) 24 (14, 32) 22 (14, 35)
post_p NA (NA, NA) 0.49 (0.11, 0.85) 0.52 (0.13, 0.88) 0.48 (0.1, 0.85) 0.46 (0.11, 0.86)
rate 0.112 (0.098, 0.129) 0.114 (0.091, 0.148) 0.11 (0.092, 0.14) 0.114 (0.098, 0.14) 0.114 (0.096, 0.138)
TEfus+ graduation 0 3 1 4 2
futility 0 29 24 17 26
max_n 0 0 2 1 0
n 152 (136, 173) 66 (33, 96) 79 (50, 104) 71 (46, 100) 71 (47, 98)
n_unique 139 (123, 159) 60 (30, 86) 72 (46, 96) 65 (42, 92) 64 (42, 89)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 24 (15, 35) 22 (10, 32) 18 (11, 33) 24 (14, 35)
post_p NA (NA, NA) 0.49 (0.1, 0.86) 0.52 (0.1, 0.88) 0.47 (0.1, 0.87) 0.47 (0.09, 0.88)
rate 0.112 (0.1, 0.125) 0.114 (0.095, 0.142) 0.112 (0.096, 0.134) 0.114 (0.097, 0.139) 0.113 (0.097, 0.139)


By subgroup combinations:
subtype var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- graduation 0 232 165 154 144
futility 0 0 0 0 0
max_n 0 17 13 12 18
n 111 (91, 132) 35 (17, 93) 32 (10, 87) 37 (10, 89) 33 (10, 91)
n_unique 103 (84, 124) 33 (16, 91) 30 (8, 84) 34 (9, 84) 31 (9, 86)
post_p NA (NA, NA) 0.45 (0.11, 0.86) 0.44 (0.08, 0.88) 0.45 (0.11, 0.89) 0.44 (0.1, 0.85)
rate 0.112 (0.099, 0.128) 0.117 (0.096, 0.154) 0.118 (0.093, 0.186) 0.115 (0.093, 0.181) 0.117 (0.095, 0.174)
—+ graduation 0 239 180 169 154
futility 0 0 0 0 0
max_n 0 17 15 13 18
n 21 (14, 28) 7 (2, 20) 9 (3, 22) 8 (2, 19) 7 (2, 18)
n_unique 19 (13, 26) 6 (2, 19) 8 (2, 21) 6 (1, 17) 6 (2, 16)
post_p NA (NA, NA) 0.48 (0.19, 0.84) 0.47 (0.18, 0.85) 0.44 (0.19, 0.82) 0.42 (0.18, 0.83)
rate 0.113 (0.084, 0.159) 0.12 (0.077, 0.276) 0.125 (0.079, 0.235) 0.128 (0.078, 0.338) 0.131 (0.078, 0.333)
–+- graduation 0 71 42 37 35
futility 0 0 0 0 0
max_n 0 7 12 6 8
n 63 (49, 77) 26 (10, 58) 23 (7, 53) 23 (7, 54) 23 (5, 54)
n_unique 57 (44, 72) 25 (9, 54) 21 (6, 49) 21 (6, 51) 21 (5, 50)
post_p NA (NA, NA) 0.45 (0.12, 0.86) 0.42 (0.12, 0.86) 0.42 (0.11, 0.84) 0.42 (0.11, 0.86)
rate 0.113 (0.094, 0.134) 0.119 (0.091, 0.173) 0.121 (0.091, 0.206) 0.121 (0.09, 0.223) 0.118 (0.089, 0.238)
–++ graduation 0 92 60 55 60
futility 0 0 0 0 0
max_n 0 7 14 7 8
n 42 (32, 52) 15 (4, 35) 22 (7, 43) 14 (4, 35) 16 (4, 35)
n_unique 37 (29, 48) 14 (4, 33) 19 (7, 40) 12 (3, 32) 15 (4, 32)
post_p NA (NA, NA) 0.44 (0.14, 0.83) 0.46 (0.12, 0.88) 0.43 (0.14, 0.83) 0.45 (0.15, 0.85)
rate 0.111 (0.091, 0.142) 0.121 (0.084, 0.228) 0.117 (0.088, 0.191) 0.124 (0.086, 0.26) 0.12 (0.086, 0.242)
-+– graduation 0 239 175 162 160
futility 0 0 0 0 0
max_n 0 17 13 12 17
n 21 (15, 28) 5 (0, 17) 7 (2, 18) 10 (3, 21) 10 (3, 21)
n_unique 19 (13, 26) 4 (0, 16) 6 (2, 16) 8 (3, 20) 9 (3, 20)
post_p NA (NA, NA) 0.48 (0.2, 0.84) 0.48 (0.18, 0.84) 0.44 (0.18, 0.84) 0.46 (0.17, 0.87)
rate 0.113 (0.085, 0.157) 0.123 (0.074, 0.332) 0.121 (0.074, 0.335) 0.126 (0.084, 0.274) 0.12 (0.08, 0.302)
-+-+ graduation 0 246 188 177 169
futility 0 0 0 0 0
max_n 0 17 15 13 17
n 21 (15, 28) 5 (0, 18) 7 (2, 18) 9 (3, 22) 10 (3, 22)
n_unique 19 (14, 26) 4 (0, 16) 6 (1, 16) 8 (3, 20) 9 (3, 20)
post_p NA (NA, NA) 0.45 (0.18, 0.83) 0.48 (0.18, 0.84) 0.43 (0.16, 0.84) 0.47 (0.17, 0.86)
rate 0.113 (0.083, 0.155) 0.13 (0.075, 0.408) 0.123 (0.073, 0.344) 0.128 (0.084, 0.289) 0.122 (0.08, 0.31)
-++- graduation 0 87 59 50 58
futility 0 0 0 0 0
max_n 0 7 12 6 8
n 12 (7, 16) 4 (1, 11) 5 (1, 10) 6 (2, 13) 6 (2, 13)
n_unique 10 (6, 15) 4 (1, 9) 4 (1, 10) 5 (2, 12) 5 (2, 12)
post_p NA (NA, NA) 0.43 (0.23, 0.8) 0.47 (0.23, 0.81) 0.47 (0.21, 0.83) 0.44 (0.2, 0.84)
rate 0.115 (0.073, 0.181) 0.134 (0.07, 0.43) 0.128 (0.064, 0.48) 0.124 (0.072, 0.33) 0.133 (0.073, 0.375)
-+++ graduation 0 107 74 68 79
futility 0 0 0 0 0
max_n 0 7 14 7 8
n 12 (7, 17) 4 (1, 11) 4 (1, 11) 6 (2, 13) 6 (2, 13)
n_unique 10 (7, 16) 4 (1, 10) 4 (1, 10) 5 (2, 12) 5 (2, 12)
post_p NA (NA, NA) 0.47 (0.21, 0.84) 0.45 (0.19, 0.81) 0.46 (0.2, 0.82) 0.44 (0.2, 0.84)
rate 0.111 (0.074, 0.182) 0.126 (0.065, 0.379) 0.132 (0.067, 0.415) 0.123 (0.07, 0.328) 0.128 (0.071, 0.411)
+— graduation 0 22 5 2 3
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 21 (14, 27) 9 (3, 19) 10 (4, 22) 8 (2, 17) 8 (3, 17)
n_unique 19 (12, 25) 8 (2, 18) 10 (3, 20) 7 (2, 16) 7 (2, 16)
post_p NA (NA, NA) 0.49 (0.19, 0.82) 0.48 (0.17, 0.86) 0.43 (0.18, 0.8) 0.45 (0.19, 0.84)
rate 0.115 (0.084, 0.161) 0.125 (0.078, 0.322) 0.121 (0.082, 0.272) 0.132 (0.076, 0.335) 0.125 (0.078, 0.301)
+–+ graduation 0 53 30 23 31
futility 0 0 0 0 0
max_n 0 0 2 1 0
n 16 (11, 22) 7 (2, 15) 9 (3, 18) 6 (2, 15) 6 (2, 14)
n_unique 15 (10, 20) 6 (2, 14) 8 (3, 16) 5 (2, 13) 5 (2, 13)
post_p NA (NA, NA) 0.46 (0.2, 0.85) 0.46 (0.2, 0.84) 0.46 (0.2, 0.82) 0.45 (0.22, 0.82)
rate 0.116 (0.086, 0.168) 0.132 (0.08, 0.354) 0.127 (0.079, 0.252) 0.13 (0.075, 0.388) 0.131 (0.074, 0.426)
+-+- graduation 0 71 42 37 35
futility 0 0 0 0 0
max_n 0 7 12 6 8
n 16 (11, 22) 6 (2, 15) 8 (3, 17) 6 (2, 14) 6 (2, 14)
n_unique 15 (10, 20) 6 (1, 14) 8 (2, 16) 6 (2, 13) 6 (2, 13)
post_p NA (NA, NA) 0.45 (0.21, 0.83) 0.48 (0.18, 0.85) 0.45 (0.2, 0.8) 0.45 (0.21, 0.81)
rate 0.113 (0.076, 0.17) 0.123 (0.072, 0.415) 0.123 (0.077, 0.289) 0.131 (0.075, 0.334) 0.129 (0.071, 0.349)
+-++ graduation 0 92 60 55 60
futility 0 0 0 0 0
max_n 0 7 14 7 8
n 16 (11, 23) 5 (2, 15) 9 (3, 17) 7 (2, 15) 6 (2, 14)
n_unique 15 (10, 21) 5 (1, 14) 8 (3, 16) 6 (2, 14) 5 (2, 13)
post_p NA (NA, NA) 0.44 (0.19, 0.82) 0.46 (0.18, 0.87) 0.45 (0.2, 0.82) 0.44 (0.18, 0.82)
rate 0.113 (0.079, 0.164) 0.133 (0.078, 0.364) 0.123 (0.077, 0.262) 0.128 (0.075, 0.335) 0.128 (0.074, 0.38)
++– graduation 0 40 24 19 29
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 12 (7, 17) 4 (1, 10) 4 (1, 11) 6 (2, 13) 6 (2, 14)
n_unique 10 (6, 16) 4 (1, 9) 4 (1, 10) 6 (2, 12) 6 (2, 13)
post_p NA (NA, NA) 0.44 (0.2, 0.8) 0.46 (0.22, 0.81) 0.47 (0.2, 0.83) 0.44 (0.22, 0.82)
rate 0.113 (0.072, 0.165) 0.137 (0.062, 0.448) 0.127 (0.063, 0.468) 0.121 (0.067, 0.331) 0.128 (0.075, 0.372)
++-+ graduation 0 69 46 39 53
futility 0 0 0 0 0
max_n 0 0 2 1 0
n 12 (7, 17) 4 (1, 10) 5 (1, 11) 6 (2, 12) 6 (2, 13)
n_unique 11 (7, 16) 4 (1, 9) 4 (1, 10) 5 (2, 11) 5 (2, 12)
post_p NA (NA, NA) 0.44 (0.2, 0.79) 0.44 (0.21, 0.78) 0.44 (0.19, 0.8) 0.45 (0.2, 0.83)
rate 0.112 (0.075, 0.17) 0.133 (0.068, 0.388) 0.134 (0.065, 0.458) 0.131 (0.073, 0.347) 0.129 (0.074, 0.357)
+++- graduation 0 87 59 50 58
futility 0 0 0 0 0
max_n 0 7 12 6 8
n 12 (7, 17) 4 (1, 10) 5 (1, 11) 6 (2, 13) 6 (2, 13)
n_unique 11 (6, 16) 4 (1, 9) 4 (1, 10) 5 (2, 12) 5 (2, 11)
post_p NA (NA, NA) 0.47 (0.22, 0.77) 0.47 (0.21, 0.82) 0.47 (0.2, 0.81) 0.44 (0.19, 0.8)
rate 0.115 (0.072, 0.182) 0.129 (0.067, 0.39) 0.127 (0.064, 0.412) 0.125 (0.074, 0.316) 0.129 (0.076, 0.386)
++++ graduation 0 107 74 68 79
futility 0 0 0 0 0
max_n 0 7 14 7 8
n 12 (7, 17) 4 (1, 11) 4 (1, 11) 6 (2, 13) 5 (2, 13)
n_unique 10 (6, 16) 4 (1, 10) 4 (1, 9) 6 (2, 12) 5 (2, 11)
post_p NA (NA, NA) 0.45 (0.24, 0.83) 0.45 (0.21, 0.82) 0.48 (0.2, 0.81) 0.43 (0.19, 0.83)
rate 0.115 (0.077, 0.174) 0.132 (0.064, 0.411) 0.131 (0.065, 0.469) 0.125 (0.074, 0.334) 0.139 (0.075, 0.386)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 11 4 1 1
time_stop 4 (4, 6) 4 (4, 11) 6 (6, 6) 7 (7, 7)
n_trt 34 (25, 50) 30 (26, 50) 25 (25, 25) 27 (27, 27)
n_control 52 (37, 61) 54 (50, 108) 51 (51, 51) 80 (80, 80)
post_p 0.87 (0.85, 0.96) 0.93 (0.92, 0.98) 0.98 (0.98, 0.98) 0.97 (0.97, 0.97)
order 1 (1, 1) 1 (1, 1) 1 (1, 1) 1 (1, 1)
TP53- & AR- count 50 44 24 22
time_stop 10 (6, 21) 14 (9, 27) 15 (10, 27) 14 (9, 21)
n_trt 31 (26, 66) 36 (26, 69) 33 (25, 68) 30 (26, 50)
n_control 43 (27, 100) 60 (40, 116) 62 (37, 125) 61 (41, 87)
post_p 0.9 (0.87, 0.95) 0.94 (0.86, 0.99) 0.94 (0.86, 0.99) 0.95 (0.9, 0.98)
order 1 (1, 1) 1 (1, 2) 1 (1, 1.7) 1 (1, 1)
TP53+ count 14 4 3 2
time_stop 10 (7, 14) 10 (8, 13) 12 (10, 13) 11 (10, 12)
n_trt 28 (25, 39) 33 (31, 42) 33 (27, 35) 39 (30, 48)
n_control 42 (32, 62) 41 (32, 59) 49 (35, 60) 42 (33, 50)
post_p 0.94 (0.86, 0.97) 0.96 (0.94, 0.98) 0.94 (0.94, 0.95) 0.92 (0.87, 0.96)
order 1 (1, 2) 1 (1, 1.7) 1 (1, 1) 1 (1, 1)
DRD+ count 3 1 2 2
time_stop 21 (15, 22) 17 (17, 17) 16 (14, 18) 10 (10, 10)
n_trt 25 (25, 34) 26 (26, 26) 27 (25, 29) 28 (26, 30)
n_control 53 (31, 64) 47 (47, 47) 35 (33, 37) 30 (26, 33)
post_p 0.98 (0.88, 0.98) 0.92 (0.92, 0.92) 0.88 (0.86, 0.9) 0.94 (0.91, 0.98)
order 1 (1, 1.8) 1 (1, 1) 1 (1, 1) 1 (1, 1)
TEfus+ count 3 1 4 2
time_stop 13 (11, 15) 11 (11, 11) 11 (10, 14) 15 (13, 17)
n_trt 26 (25, 32) 31 (31, 31) 28 (26, 29) 41 (39, 43)
n_control 44 (40, 52) 36 (36, 36) 42 (40, 50) 50 (40, 60)
post_p 0.9 (0.87, 0.94) 0.95 (0.95, 0.95) 0.93 (0.87, 0.99) 1 (1, 1)
order 1 (1, 1.8) 1 (1, 1) 1 (1, 1.7) 1 (1, 1)
Futility:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 11 1 1 2
time_stop 5 (3, 5) 6 (6, 6) 7 (7, 7) 12 (8, 16)
n_trt 31 (25, 39) 28 (28, 28) 38 (38, 38) 41 (32, 50)
n_control 43 (33, 66) 75 (75, 75) 64 (64, 64) 140 (92, 187)
post_p 0.04 (0.03, 0.28) 0.14 (0.14, 0.14) 0.01 (0.01, 0.01) 0.06 (0.01, 0.11)
order 1 (1, 1) 1 (1, 1) 1 (1, 1) 1.5 (1.1, 1.9)
TP53- & AR- count 161 116 128 119
time_stop 15 (8, 32) 22 (15, 33) 22 (14, 34) 22 (14, 33)
n_trt 36 (25, 75) 36 (25, 72) 34 (25, 80) 39 (26, 84)
n_control 65 (30, 147) 101 (66, 158) 102 (59, 167) 101 (59, 159)
post_p 0.17 (0.06, 0.28) 0.12 (0.03, 0.27) 0.16 (0.04, 0.26) 0.16 (0.06, 0.28)
order 1 (1, 2) 2 (1, 3) 1 (1, 3) 2 (1, 3)
TP53+ count 38 33 32 31
time_stop 20 (10, 28) 18 (10, 29) 22 (14, 34) 22 (13, 33)
n_trt 42 (26, 69) 41 (28, 69) 44 (26, 75) 45 (27, 74)
n_control 94 (38, 139) 85 (42, 159) 100 (66, 182) 107 (59, 171)
post_p 0.06 (0.01, 0.22) 0.07 (0.03, 0.21) 0.05 (0.01, 0.15) 0.05 (0, 0.13)
order 1 (1, 3) 2 (1, 3) 1 (1, 3) 2 (1, 4)
DRD+ count 16 18 15 25
time_stop 31 (22, 35) 28 (22, 33) 24 (16, 33) 23 (16, 36)
n_trt 32 (26, 49) 31 (25, 49) 37 (25, 51) 34 (28, 54)
n_control 98 (64, 120) 84 (55, 99) 68 (45, 90) 69 (40, 114)
post_p 0.05 (0.02, 0.15) 0.04 (0.01, 0.19) 0.08 (0.02, 0.18) 0.04 (0.02, 0.17)
order 2 (1.5, 4) 2.5 (1.7, 4) 3 (1.4, 4) 2 (1, 3)
TEfus+ count 29 24 17 26
time_stop 25 (18, 35) 22 (11, 32) 20 (13, 33) 24 (14, 36)
n_trt 34 (26, 49) 40 (28, 62) 33 (26, 49) 44 (26, 70)
n_control 105 (65, 140) 90 (36, 126) 88 (49, 137) 93 (46, 150)
post_p 0.05 (0.02, 0.13) 0.05 (0.01, 0.13) 0.05 (0.02, 0.11) 0.04 (0.01, 0.16)
order 2 (1, 4) 1.5 (1, 3) 2 (1, 3.4) 2 (1, 3.5)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11
time 4 (4, 6) 4 (4, 6) 4 (4, 6) 4 (4, 6) 4 (4, 6) 4 (4, 6) 4 (4, 6) 4 (4, 6) 4 (4, 6) 4 (4, 6) 4 (4, 6) 4 (4, 6) 4 (4, 6) 4 (4, 6) 4 (4, 6) 4 (4, 6)
n 14 (11, 19) 1 (1, 3) 9 (8, 18) 2 (0, 5) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 3) 1 (1, 3) 1 (1, 3) 1 (0, 1) 0 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1)
post_p 0.64 (0.55, 0.88) 0.58 (0.54, 0.65) 0.73 (0.62, 0.83) 0.59 (0.53, 0.71) NA (NA, NA) 0.54 (0.54, 0.63) NA (NA, NA) 0.6 (0.52, 0.77) 0.55 (0.51, 0.69) 0.59 (0.51, 0.7) 0.62 (0.54, 0.64) 0.6 (0.54, 0.6) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.61 (0.56, 0.65)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.078 (0.047, 0.113) 0 (0, 0.007) 0.057 (0, 0.092) 0 (0, 0.305) NA (NA, NA) 0 (0, 0.112) NA (NA, NA) 0 (0, 0) 0 (0, 0.077) 0 (0, 0) 0 (0, 0) 0 (0, 0.088) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0)
Taxel_therapies count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
time 4 (4, 11) 4 (4, 11) 4 (4, 11) 4 (4, 11) 4 (4, 11) 4 (4, 11) 4 (4, 11) 4 (4, 11) 4 (4, 11) 4 (4, 11) 4 (4, 11) 4 (4, 11) 4 (4, 11) 4 (4, 11) 4 (4, 11) 4 (4, 11)
n 6 (4, 8) 2 (1, 5) 7 (2, 8) 6 (4, 8) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 4) 4 (2, 6) 4 (2, 4) 4 (1, 6) 0 (0, 2) 0 (0, 0) 0 (0, 2) 0 (0, 0)
post_p 0.71 (0.61, 0.83) 0.58 (0.54, 0.69) 0.64 (0.63, 0.75) 0.72 (0.65, 0.8) 0.59 (0.59, 0.59) 0.61 (0.61, 0.61) 0.55 (0.53, 0.58) 0.52 (0.52, 0.52) 0.64 (0.63, 0.64) 0.6 (0.51, 0.83) 0.61 (0.53, 0.72) 0.58 (0.53, 0.83) 0.51 (0.51, 0.51) NA (NA, NA) 0.57 (0.57, 0.57) NA (NA, NA)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.038 (0, 0.099) 0 (0, 0.121) 0.068 (0.014, 0.096) 0 (0, 0.049) 0.119 (0.119, 0.119) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.163 (0.091, 0.235) 0 (0, 0) 0.033 (0, 0.187) 0.114 (0.023, 0.252) 0 (0, 0) NA (NA, NA) 0.073 (0.073, 0.073) NA (NA, NA)
Carboplatin count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6)
n 6 (6, 6) 0 (0, 0) 4 (4, 4) 0 (0, 0) 2 (2, 2) 4 (4, 4) 0 (0, 0) 2 (2, 2) 1 (1, 1) 0 (0, 0) 2 (2, 2) 0 (0, 0) 1 (1, 1) 1 (1, 1) 1 (1, 1) 1 (1, 1)
post_p 0.56 (0.56, 0.56) NA (NA, NA) 0.56 (0.56, 0.56) NA (NA, NA) 0.67 (0.67, 0.67) 0.73 (0.73, 0.73) NA (NA, NA) 0.58 (0.58, 0.58) 0.62 (0.62, 0.62) NA (NA, NA) 0.59 (0.59, 0.59) NA (NA, NA) 0.63 (0.63, 0.63) 0.51 (0.51, 0.51) 0.54 (0.54, 0.54) 0.52 (0.52, 0.52)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.091 (0.091, 0.091) NA (NA, NA) 0.087 (0.087, 0.087) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
Niraparib count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7)
n 2 (2, 2) 0 (0, 0) 4 (4, 4) 2 (2, 2) 6 (6, 6) 0 (0, 0) 0 (0, 0) 1 (1, 1) 1 (1, 1) 2 (2, 2) 0 (0, 0) 1 (1, 1) 0 (0, 0) 4 (4, 4) 2 (2, 2) 2 (2, 2)
post_p 0.54 (0.54, 0.54) NA (NA, NA) 0.7 (0.7, 0.7) 0.61 (0.61, 0.61) 0.62 (0.62, 0.62) NA (NA, NA) NA (NA, NA) 0.58 (0.58, 0.58) 0.51 (0.51, 0.51) 0.51 (0.51, 0.51) NA (NA, NA) 0.54 (0.54, 0.54) NA (NA, NA) 0.73 (0.73, 0.73) 0.64 (0.64, 0.64) 0.82 (0.82, 0.82)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0.044 (0.044, 0.044) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0.068 (0.068, 0.068) 0 (0, 0) 0 (0, 0)
TP53- & AR- Hormone_therapies count 50 50 50 50
time 10 (6, 21) 10 (6, 21) 10 (6, 21) 10 (6, 21)
n 26 (21, 50) 4 (2, 8) 1 (0, 5) 1 (0, 10)
post_p 0.85 (0.74, 0.92) 0.69 (0.55, 0.83) 0.57 (0.51, 0.72) 0.54 (0.52, 0.8)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.081 (0.051, 0.097) 0.062 (0, 0.126) 0 (0, 0.095) 0 (0, 0.106)
Taxel_therapies count 44 44 44 44
time 14 (9, 27) 14 (9, 27) 14 (9, 27) 14 (9, 27)
n 22 (18, 39) 5 (1, 12) 3 (1, 12) 3 (0, 8)
post_p 0.83 (0.72, 0.96) 0.73 (0.53, 0.89) 0.62 (0.52, 0.83) 0.67 (0.52, 0.86)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.076 (0.037, 0.099) 0.065 (0, 0.122) 0.057 (0, 0.113) 0.058 (0, 0.141)
Carboplatin count 24 24 24 24
time 15 (10, 27) 15 (10, 27) 15 (10, 27) 15 (10, 27)
n 19 (10, 42) 4 (0, 12) 6 (4, 12) 6 (2, 11)
post_p 0.81 (0.71, 0.92) 0.69 (0.59, 0.85) 0.78 (0.53, 0.91) 0.71 (0.52, 0.85)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.07 (0.027, 0.095) 0.056 (0, 0.109) 0.068 (0.033, 0.142) 0.08 (0.039, 0.147)
Niraparib count 22 22 22 22
time 14 (9, 21) 14 (9, 21) 14 (9, 21) 14 (9, 21)
n 18 (12, 34) 2 (0, 6) 6 (3, 11) 5 (3, 11)
post_p 0.8 (0.73, 0.9) 0.61 (0.52, 0.82) 0.78 (0.59, 0.89) 0.72 (0.54, 0.88)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.07 (0.028, 0.083) 0.036 (0, 0.108) 0.061 (0.003, 0.115) 0.075 (0.002, 0.106)
TP53+ Hormone_therapies count 14 14 14 14 14 14 14 14
time 10 (7, 14) 10 (7, 14) 10 (7, 14) 10 (7, 14) 10 (7, 14) 10 (7, 14) 10 (7, 14) 10 (7, 14)
n 15 (11, 18) 6 (2, 11) 0 (0, 3) 1 (0, 4) 2 (0, 5) 3 (0, 5) 0 (0, 3) 1 (0, 2)
post_p 0.8 (0.71, 0.88) 0.75 (0.56, 0.86) 0.55 (0.52, 0.64) 0.59 (0.53, 0.69) 0.7 (0.58, 0.76) 0.61 (0.55, 0.73) 0.62 (0.56, 0.73) 0.61 (0.55, 0.79)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.077 (0.043, 0.108) 0.064 (0, 0.102) 0 (0, 0.041) 0 (0, 0.087) 0 (0, 0.088) 0.032 (0, 0.121) 0 (0, 0.151) 0 (0, 0.031)
Taxel_therapies count 4 4 4 4 4 4 4 4
time 10 (8, 13) 10 (8, 13) 10 (8, 13) 10 (8, 13) 10 (8, 13) 10 (8, 13) 10 (8, 13) 10 (8, 13)
n 11 (10, 13) 12 (8, 18) 2 (0, 3) 0 (0, 1) 2 (1, 3) 4 (3, 6) 1 (1, 2) 2 (0, 3)
post_p 0.78 (0.72, 0.84) 0.83 (0.76, 0.88) 0.55 (0.53, 0.7) 0.56 (0.56, 0.56) 0.57 (0.52, 0.66) 0.68 (0.53, 0.78) 0.67 (0.56, 0.68) 0.6 (0.53, 0.65)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.07 (0.016, 0.093) 0.066 (0.044, 0.07) 0 (0, 0.028) 0 (0, 0) 0.074 (0, 0.177) 0.098 (0.057, 0.149) 0 (0, 0.297) 0 (0, 0.07)
Carboplatin count 3 3 3 3 3 3 3 3
time 12 (10, 13) 12 (10, 13) 12 (10, 13) 12 (10, 13) 12 (10, 13) 12 (10, 13) 12 (10, 13) 12 (10, 13)
n 12 (6, 17) 4 (3, 4) 3 (2, 5) 5 (1, 5) 2 (1, 5) 1 (0, 3) 1 (1, 2) 4 (2, 5)
post_p 0.78 (0.58, 0.82) 0.57 (0.53, 0.67) 0.57 (0.54, 0.58) 0.84 (0.74, 0.95) 0.72 (0.61, 0.75) 0.53 (0.51, 0.54) 0.64 (0.55, 0.67) 0.61 (0.56, 0.82)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.053 (0.022, 0.154) 0.071 (0.067, 0.073) 0.081 (0.059, 0.153) 0.03 (0.024, 0.036) 0.092 (0.018, 0.101) 0.056 (0.011, 0.102) 0.099 (0.02, 0.11) 0 (0, 0.104)
Niraparib count 2 2 2 2 2 2 2 2
time 11 (10, 12) 11 (10, 12) 11 (10, 12) 11 (10, 12) 11 (10, 12) 11 (10, 12) 11 (10, 12) 11 (10, 12)
n 15 (10, 20) 2 (2, 3) 4 (4, 5) 3 (2, 4) 4 (3, 5) 2 (1, 2) 4 (2, 5) 5 (3, 7)
post_p 0.76 (0.72, 0.8) 0.64 (0.59, 0.69) 0.64 (0.58, 0.71) 0.57 (0.52, 0.62) 0.7 (0.7, 0.7) 0.56 (0.53, 0.59) 0.55 (0.54, 0.56) 0.76 (0.74, 0.78)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.069 (0.068, 0.07) 0 (0, 0) 0.08 (0.072, 0.088) 0.122 (0.094, 0.15) 0.031 (0.006, 0.055) 0 (0, 0) 0.119 (0.102, 0.136) 0.027 (0.005, 0.049)
DRD+ Hormone_therapies count 3 3 3 3 3 3 3 3
time 21 (15, 22) 21 (15, 22) 21 (15, 22) 21 (15, 22) 21 (15, 22) 21 (15, 22) 21 (15, 22) 21 (15, 22)
n 5 (1, 5) 9 (3, 11) 3 (1, 8) 4 (1, 4) 1 (1, 3) 5 (2, 6) 4 (2, 5) 3 (1, 3)
post_p 0.6 (0.57, 0.62) 0.78 (0.68, 0.89) 0.68 (0.54, 0.83) 0.59 (0.56, 0.62) 0.65 (0.63, 0.69) 0.68 (0.62, 0.76) 0.56 (0.53, 0.59) 0.68 (0.58, 0.82)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.098 (0.092, 0.103) 0.084 (0.046, 0.09) 0.102 (0.05, 0.154) 0.084 (0.068, 0.099) 0 (0, 0) 0.087 (0.065, 0.124) 0.08 (0.016, 0.174) 0 (0, 0.045)
Taxel_therapies count 1 1 1 1 1 1 1 1
time 17 (17, 17) 17 (17, 17) 17 (17, 17) 17 (17, 17) 17 (17, 17) 17 (17, 17) 17 (17, 17) 17 (17, 17)
n 3 (3, 3) 5 (5, 5) 2 (2, 2) 1 (1, 1) 1 (1, 1) 3 (3, 3) 9 (9, 9) 2 (2, 2)
post_p 0.6 (0.6, 0.6) 0.57 (0.57, 0.57) 0.85 (0.85, 0.85) 0.68 (0.68, 0.68) 0.74 (0.74, 0.74) 0.61 (0.61, 0.61) 0.81 (0.81, 0.81) 0.54 (0.54, 0.54)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.051 (0.051, 0.051) 0.094 (0.094, 0.094) 0.064 (0.064, 0.064) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.077 (0.077, 0.077) 0 (0, 0)
Carboplatin count 2 2 2 2 2 2 2 2
time 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18)
n 6 (4, 8) 4 (2, 5) 4 (4, 4) 2 (0, 3) 2 (0, 4) 2 (2, 3) 2 (1, 4) 4 (2, 7)
post_p 0.66 (0.59, 0.73) 0.56 (0.55, 0.57) 0.62 (0.6, 0.64) 0.56 (0.56, 0.56) 0.77 (0.77, 0.77) 0.65 (0.61, 0.68) 0.57 (0.54, 0.6) 0.71 (0.55, 0.87)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.069 (0.033, 0.105) 0.127 (0.124, 0.13) 0.061 (0.052, 0.069) 0.201 (0.201, 0.201) 0.057 (0.057, 0.057) 0.064 (0.013, 0.116) 0.03 (0.006, 0.054) 0.054 (0.011, 0.098)
Niraparib count 2 2 2 2 2 2 2 2
time 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10)
n 3 (3, 3) 6 (5, 7) 2 (2, 3) 2 (2, 3) 3 (2, 4) 4 (4, 5) 3 (3, 3) 4 (2, 6)
post_p 0.64 (0.59, 0.68) 0.74 (0.7, 0.79) 0.83 (0.81, 0.84) 0.72 (0.62, 0.82) 0.61 (0.6, 0.62) 0.75 (0.64, 0.86) 0.55 (0.55, 0.56) 0.67 (0.54, 0.8)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.036 (0.007, 0.064) 0.101 (0.068, 0.133) 0 (0, 0) 0.107 (0.021, 0.193) 0.029 (0.006, 0.052) 0.035 (0.034, 0.036) 0.117 (0.114, 0.12) 0.039 (0.008, 0.07)
TEfus+ Hormone_therapies count 3 3 3 3 3 3 3 3
time 13 (11, 15) 13 (11, 15) 13 (11, 15) 13 (11, 15) 13 (11, 15) 13 (11, 15) 13 (11, 15) 13 (11, 15)
n 4 (2, 5) 13 (12, 17) 2 (1, 6) 0 (0, 2) 3 (1, 4) 3 (1, 4) 0 (0, 1) 0 (0, 1)
post_p 0.66 (0.6, 0.71) 0.73 (0.71, 0.75) 0.56 (0.55, 0.88) 0.62 (0.62, 0.62) 0.77 (0.65, 0.78) 0.58 (0.54, 0.63) 0.56 (0.56, 0.56) NA (NA, NA)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.098 (0.02, 0.099) 0.091 (0.076, 0.104) 0.032 (0.006, 0.085) 0 (0, 0) 0.079 (0.016, 0.1) 0.066 (0.059, 0.074) 0 (0, 0) 0 (0, 0)
Taxel_therapies count 1 1 1 1 1 1 1 1
time 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11)
n 1 (1, 1) 19 (19, 19) 2 (2, 2) 0 (0, 0) 2 (2, 2) 6 (6, 6) 1 (1, 1) 0 (0, 0)
post_p 0.73 (0.73, 0.73) 0.82 (0.82, 0.82) 0.6 (0.6, 0.6) NA (NA, NA) 0.63 (0.63, 0.63) 0.77 (0.77, 0.77) 0.61 (0.61, 0.61) NA (NA, NA)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0 (0, 0) 0.031 (0.031, 0.031) 0 (0, 0) NA (NA, NA) 0.169 (0.169, 0.169) 0.163 (0.163, 0.163) 0 (0, 0) NA (NA, NA)
Carboplatin count 4 4 4 4 4 4 4 4
time 11 (10, 14) 11 (10, 14) 11 (10, 14) 11 (10, 14) 11 (10, 14) 11 (10, 14) 11 (10, 14) 11 (10, 14)
n 4 (2, 7) 4 (2, 8) 6 (3, 7) 4 (3, 5) 4 (2, 5) 0 (0, 2) 2 (0, 4) 4 (2, 4)
post_p 0.74 (0.6, 0.86) 0.62 (0.57, 0.85) 0.64 (0.51, 0.85) 0.61 (0.54, 0.85) 0.57 (0.52, 0.73) 0.54 (0.54, 0.55) 0.71 (0.61, 0.8) 0.58 (0.56, 0.65)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.027 (0, 0.083) 0 (0, 0.079) 0.061 (0.053, 0.09) 0.073 (0.059, 0.1) 0.042 (0, 0.135) 0 (0, 0) 0.094 (0.082, 0.106) 0.09 (0.073, 0.097)
Niraparib count 2 2 2 2 2 2 2 2
time 15 (13, 17) 15 (13, 17) 15 (13, 17) 15 (13, 17) 15 (13, 17) 15 (13, 17) 15 (13, 17) 15 (13, 17)
n 4 (3, 4) 12 (11, 14) 6 (5, 8) 6 (4, 8) 4 (2, 6) 1 (1, 1) 4 (3, 5) 4 (3, 4)
post_p 0.56 (0.53, 0.58) 0.83 (0.81, 0.86) 0.75 (0.72, 0.78) 0.77 (0.76, 0.79) 0.75 (0.7, 0.8) 0.56 (0.53, 0.6) 0.68 (0.63, 0.73) 0.58 (0.57, 0.6)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.119 (0.112, 0.127) 0.045 (0.044, 0.046) 0.051 (0.043, 0.059) 0.02 (0.004, 0.037) 0.033 (0.007, 0.06) 0 (0, 0) 0.13 (0.074, 0.185) 0.074 (0.069, 0.078)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11
time 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5) 5 (3, 5)
n 15 (12, 19) 2 (0, 5) 6 (4, 11) 2 (2, 5) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 1) 1 (0, 3) 1 (0, 2) 0 (0, 3) 1 (0, 4) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 1)
post_p 0.29 (0.18, 0.47) 0.39 (0.32, 0.45) 0.25 (0.14, 0.37) 0.38 (0.29, 0.47) 0.39 (0.27, 0.49) 0.29 (0.29, 0.29) 0.28 (0.25, 0.32) 0.4 (0.4, 0.4) 0.48 (0.39, 0.49) 0.3 (0.26, 0.4) 0.31 (0.27, 0.35) 0.4 (0.28, 0.47) 0.35 (0.31, 0.4) 0.42 (0.42, 0.42) 0.43 (0.4, 0.47) 0.28 (0.28, 0.28)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.162 (0.096, 0.21) 0.244 (0.115, 0.427) 0.204 (0.077, 0.398) 0.19 (0.114, 1.114) 0.067 (0, 0.682) 0.356 (0.356, 0.356) 0.433 (0.087, 0.945) 0.098 (0.02, 0.177) 0.151 (0, 0.439) 0.463 (0.193, 0.988) 0.114 (0, 0.537) 0 (0, 0.214) 3.829 (0.863, 6.794) 0.351 (0.351, 0.351) 0.087 (0.017, 0.157) 0 (0, 0.291)
Taxel_therapies count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6)
n 6 (6, 6) 1 (1, 1) 3 (3, 3) 6 (6, 6) 0 (0, 0) 0 (0, 0) 0 (0, 0) 1 (1, 1) 1 (1, 1) 2 (2, 2) 4 (4, 4) 4 (4, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
post_p 0.48 (0.48, 0.48) 0.46 (0.46, 0.46) 0.44 (0.44, 0.44) 0.32 (0.32, 0.32) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.44 (0.44, 0.44) 0.5 (0.5, 0.5) 0.43 (0.43, 0.43) 0.28 (0.28, 0.28) 0.33 (0.33, 0.33) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.118 (0.118, 0.118) 0 (0, 0) 0.183 (0.183, 0.183) 0.228 (0.228, 0.228) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0.167 (0.167, 0.167) 0.178 (0.178, 0.178) 0.145 (0.145, 0.145) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
Carboplatin count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7)
n 5 (5, 5) 2 (2, 2) 6 (6, 6) 3 (3, 3) 0 (0, 0) 1 (1, 1) 2 (2, 2) 2 (2, 2) 5 (5, 5) 0 (0, 0) 2 (2, 2) 2 (2, 2) 4 (4, 4) 3 (3, 3) 0 (0, 0) 1 (1, 1)
post_p 0.28 (0.28, 0.28) 0.38 (0.38, 0.38) 0.28 (0.28, 0.28) 0.43 (0.43, 0.43) NA (NA, NA) 0.23 (0.23, 0.23) 0.21 (0.21, 0.21) 0.27 (0.27, 0.27) 0.35 (0.35, 0.35) NA (NA, NA) 0.36 (0.36, 0.36) 0.47 (0.47, 0.47) 0.4 (0.4, 0.4) 0.38 (0.38, 0.38) NA (NA, NA) 0.47 (0.47, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.248 (0.248, 0.248) 0.269 (0.269, 0.269) 0.179 (0.179, 0.179) 0.164 (0.164, 0.164) NA (NA, NA) 2.439 (2.439, 2.439) 1.674 (1.674, 1.674) 0.9 (0.9, 0.9) 0.192 (0.192, 0.192) NA (NA, NA) 0.32 (0.32, 0.32) 0.335 (0.335, 0.335) 0.153 (0.153, 0.153) 0.083 (0.083, 0.083) NA (NA, NA) 0 (0, 0)
Niraparib count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
time 12 (8, 16) 12 (8, 16) 12 (8, 16) 12 (8, 16) 12 (8, 16) 12 (8, 16) 12 (8, 16) 12 (8, 16) 12 (8, 16) 12 (8, 16) 12 (8, 16) 12 (8, 16) 12 (8, 16) 12 (8, 16) 12 (8, 16) 12 (8, 16)
n 4 (3, 4) 2 (0, 3) 7 (6, 8) 2 (0, 3) 4 (2, 5) 6 (5, 7) 3 (1, 5) 1 (1, 1) 0 (0, 1) 2 (1, 3) 0 (0, 1) 1 (0, 2) 2 (1, 2) 4 (4, 4) 4 (2, 6) 0 (0, 1)
post_p 0.37 (0.33, 0.41) 0.24 (0.24, 0.24) 0.28 (0.13, 0.42) 0.16 (0.16, 0.16) 0.36 (0.31, 0.41) 0.35 (0.35, 0.36) 0.39 (0.39, 0.39) 0.33 (0.33, 0.33) 0.32 (0.32, 0.32) 0.36 (0.34, 0.38) 0.46 (0.46, 0.46) 0.44 (0.44, 0.44) 0.26 (0.24, 0.28) 0.36 (0.34, 0.37) 0.37 (0.34, 0.4) 0.45 (0.45, 0.45)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.228 (0.225, 0.23) 0.52 (0.52, 0.52) 0.164 (0.142, 0.185) 0.283 (0.283, 0.283) 0.366 (0.177, 0.555) 0.137 (0.117, 0.157) 0.103 (0.103, 0.103) 0.294 (0.226, 0.361) 0.733 (0.733, 0.733) 2.82 (0.687, 4.954) 0.293 (0.293, 0.293) 0 (0, 0) 1.243 (0.446, 2.039) 0.164 (0.152, 0.177) 4.739 (1.034, 8.444) 0.143 (0.143, 0.143)
TP53- & AR- Hormone_therapies count 161 161 161 161
time 15 (8, 32) 15 (8, 32) 15 (8, 32) 15 (8, 32)
n 25 (17, 54) 5 (2, 10) 3 (0, 8) 3 (1, 8)
post_p 0.33 (0.14, 0.46) 0.36 (0.17, 0.48) 0.38 (0.21, 0.48) 0.37 (0.2, 0.49)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.126 (0.105, 0.16) 0.175 (0.1, 0.439) 0.171 (0.102, 0.509) 0.175 (0.099, 0.553)
Taxel_therapies count 116 116 116 116
time 22 (15, 33) 22 (15, 33) 22 (15, 33) 22 (15, 33)
n 19 (9, 52) 6 (2, 14) 5 (2, 10) 4 (2, 10)
post_p 0.29 (0.07, 0.45) 0.35 (0.16, 0.47) 0.37 (0.17, 0.48) 0.36 (0.21, 0.48)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.135 (0.106, 0.207) 0.144 (0.103, 0.347) 0.164 (0.106, 0.529) 0.153 (0.104, 0.44)
Carboplatin count 128 128 128 128
time 22 (14, 34) 22 (14, 34) 22 (14, 34) 22 (14, 34)
n 18 (7, 52) 4 (1, 11) 7 (2, 13) 6 (2, 13)
post_p 0.35 (0.11, 0.47) 0.34 (0.19, 0.48) 0.36 (0.2, 0.47) 0.34 (0.16, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.128 (0.107, 0.25) 0.165 (0.108, 0.666) 0.156 (0.108, 0.328) 0.159 (0.104, 0.6)
Niraparib count 119 119 119 119
time 22 (14, 33) 22 (14, 33) 22 (14, 33) 22 (14, 33)
n 22 (8, 57) 4 (1, 10) 7 (3, 14) 6 (2, 13)
post_p 0.35 (0.11, 0.47) 0.36 (0.21, 0.47) 0.36 (0.15, 0.48) 0.35 (0.13, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.127 (0.101, 0.188) 0.162 (0.11, 0.517) 0.144 (0.101, 0.457) 0.156 (0.106, 0.422)
TP53+ Hormone_therapies count 38 38 38 38 38 38 38 38
time 20 (10, 28) 20 (10, 28) 20 (10, 28) 20 (10, 28) 20 (10, 28) 20 (10, 28) 20 (10, 28) 20 (10, 28)
n 16 (9, 36) 7 (2, 19) 2 (0, 4) 2 (0, 6) 4 (1, 7) 3 (1, 5) 2 (0, 6) 2 (1, 4)
post_p 0.32 (0.09, 0.47) 0.32 (0.12, 0.48) 0.35 (0.22, 0.47) 0.36 (0.19, 0.48) 0.36 (0.25, 0.48) 0.34 (0.17, 0.46) 0.38 (0.29, 0.44) 0.4 (0.27, 0.48)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.129 (0.103, 0.182) 0.149 (0.109, 0.614) 0.212 (0.099, 0.94) 0.209 (0.102, 0.923) 0.184 (0.101, 1.892) 0.21 (0.111, 0.478) 0.205 (0.099, 0.758) 0.202 (0.087, 0.348)
Taxel_therapies count 33 33 33 33 33 33 33 33
time 18 (10, 29) 18 (10, 29) 18 (10, 29) 18 (10, 29) 18 (10, 29) 18 (10, 29) 18 (10, 29) 18 (10, 29)
n 10 (4, 36) 10 (5, 18) 1 (0, 5) 2 (0, 7) 4 (1, 8) 5 (1, 10) 2 (0, 6) 3 (1, 5)
post_p 0.35 (0.21, 0.46) 0.33 (0.15, 0.45) 0.4 (0.25, 0.49) 0.38 (0.2, 0.48) 0.39 (0.23, 0.49) 0.36 (0.2, 0.48) 0.36 (0.19, 0.49) 0.32 (0.19, 0.48)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.131 (0.111, 0.215) 0.133 (0.092, 0.191) 0.214 (0.088, 0.673) 0.212 (0.09, 0.814) 0.159 (0.112, 0.318) 0.145 (0.081, 0.455) 0.206 (0.139, 1) 0.202 (0.081, 0.791)
Carboplatin count 32 32 32 32 32 32 32 32
time 22 (14, 34) 22 (14, 34) 22 (14, 34) 22 (14, 34) 22 (14, 34) 22 (14, 34) 22 (14, 34) 22 (14, 34)
n 13 (4, 29) 7 (2, 14) 3 (1, 7) 3 (1, 8) 5 (2, 11) 4 (1, 7) 4 (2, 7) 4 (1, 9)
post_p 0.35 (0.1, 0.46) 0.35 (0.14, 0.46) 0.34 (0.18, 0.47) 0.36 (0.16, 0.45) 0.4 (0.23, 0.48) 0.33 (0.15, 0.48) 0.37 (0.23, 0.48) 0.39 (0.22, 0.47)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.137 (0.104, 0.325) 0.147 (0.109, 0.434) 0.19 (0.099, 0.622) 0.191 (0.097, 0.948) 0.144 (0.109, 0.357) 0.192 (0.115, 0.343) 0.166 (0.098, 0.427) 0.168 (0.093, 0.31)
Niraparib count 31 31 31 31 31 31 31 31
time 22 (13, 33) 22 (13, 33) 22 (13, 33) 22 (13, 33) 22 (13, 33) 22 (13, 33) 22 (13, 33) 22 (13, 33)
n 9 (3, 26) 9 (4, 23) 4 (1, 7) 3 (2, 6) 4 (1, 8) 2 (1, 9) 5 (2, 7) 4 (1, 9)
post_p 0.28 (0.15, 0.41) 0.32 (0.16, 0.48) 0.36 (0.23, 0.47) 0.33 (0.15, 0.48) 0.34 (0.18, 0.45) 0.36 (0.18, 0.46) 0.43 (0.19, 0.49) 0.35 (0.17, 0.48)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.14 (0.115, 0.371) 0.155 (0.107, 0.335) 0.172 (0.106, 0.387) 0.202 (0.125, 0.425) 0.187 (0.124, 0.404) 0.255 (0.118, 0.856) 0.126 (0.09, 0.344) 0.195 (0.117, 0.63)
DRD+ Hormone_therapies count 16 16 16 16 16 16 16 16
time 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35) 31 (22, 35)
n 4 (2, 19) 4 (2, 7) 4 (2, 9) 4 (2, 8) 3 (2, 6) 3 (2, 6) 3 (0, 8) 3 (2, 5)
post_p 0.38 (0.19, 0.49) 0.28 (0.13, 0.45) 0.32 (0.25, 0.45) 0.4 (0.3, 0.45) 0.33 (0.25, 0.46) 0.33 (0.18, 0.44) 0.35 (0.2, 0.45) 0.37 (0.18, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.142 (0.108, 0.34) 0.188 (0.129, 0.591) 0.157 (0.115, 0.428) 0.165 (0.097, 0.615) 0.186 (0.133, 0.281) 0.217 (0.14, 0.334) 0.18 (0.142, 0.4) 0.191 (0.144, 0.38)
Taxel_therapies count 18 18 18 18 18 18 18 18
time 28 (22, 33) 28 (22, 33) 28 (22, 33) 28 (22, 33) 28 (22, 33) 28 (22, 33) 28 (22, 33) 28 (22, 33)
n 6 (2, 13) 3 (1, 12) 3 (1, 7) 4 (1, 6) 4 (1, 7) 4 (1, 6) 3 (2, 7) 2 (1, 5)
post_p 0.41 (0.23, 0.48) 0.37 (0.2, 0.48) 0.35 (0.24, 0.48) 0.35 (0.12, 0.46) 0.35 (0.23, 0.47) 0.35 (0.18, 0.47) 0.37 (0.2, 0.47) 0.34 (0.19, 0.46)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.159 (0.107, 0.344) 0.176 (0.113, 2.086) 0.174 (0.093, 0.543) 0.208 (0.119, 0.684) 0.179 (0.116, 0.516) 0.228 (0.128, 0.618) 0.168 (0.114, 0.376) 0.212 (0.123, 0.473)
Carboplatin count 15 15 15 15 15 15 15 15
time 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33)
n 7 (1, 15) 6 (2, 11) 2 (0, 7) 3 (2, 6) 4 (1, 7) 3 (1, 7) 5 (2, 10) 4 (2, 7)
post_p 0.4 (0.25, 0.46) 0.39 (0.18, 0.46) 0.3 (0.24, 0.46) 0.34 (0.2, 0.45) 0.38 (0.28, 0.45) 0.36 (0.2, 0.45) 0.33 (0.24, 0.47) 0.37 (0.24, 0.49)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.163 (0.122, 0.331) 0.149 (0.107, 0.4) 0.207 (0.124, 0.577) 0.207 (0.112, 0.431) 0.189 (0.121, 0.809) 0.196 (0.14, 1.101) 0.183 (0.093, 0.425) 0.189 (0.135, 0.343)
Niraparib count 25 25 25 25 25 25 25 25
time 23 (16, 36) 23 (16, 36) 23 (16, 36) 23 (16, 36) 23 (16, 36) 23 (16, 36) 23 (16, 36) 23 (16, 36)
n 6 (3, 12) 5 (2, 12) 4 (2, 8) 3 (1, 9) 3 (2, 8) 3 (2, 7) 3 (2, 11) 4 (1, 9)
post_p 0.38 (0.13, 0.48) 0.34 (0.2, 0.47) 0.34 (0.22, 0.49) 0.33 (0.14, 0.48) 0.33 (0.16, 0.49) 0.36 (0.16, 0.45) 0.36 (0.22, 0.47) 0.35 (0.21, 0.48)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.161 (0.102, 0.347) 0.164 (0.117, 0.312) 0.174 (0.1, 0.541) 0.196 (0.109, 0.623) 0.186 (0.094, 0.75) 0.169 (0.122, 0.38) 0.197 (0.085, 0.368) 0.18 (0.127, 0.524)
TEfus+ Hormone_therapies count 29 29 29 29 29 29 29 29
time 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35) 25 (18, 35)
n 5 (2, 11) 8 (5, 20) 2 (0, 6) 3 (1, 7) 3 (1, 8) 4 (2, 7) 2 (1, 7) 2 (1, 4)
post_p 0.35 (0.21, 0.48) 0.31 (0.12, 0.44) 0.35 (0.24, 0.46) 0.37 (0.19, 0.48) 0.31 (0.19, 0.45) 0.37 (0.21, 0.48) 0.35 (0.18, 0.47) 0.35 (0.26, 0.48)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.177 (0.11, 0.494) 0.142 (0.116, 0.284) 0.212 (0.113, 0.916) 0.206 (0.106, 0.467) 0.226 (0.118, 0.726) 0.177 (0.123, 0.447) 0.223 (0.118, 0.585) 0.234 (0.111, 0.376)
Taxel_therapies count 24 24 24 24 24 24 24 24
time 22 (11, 32) 22 (11, 32) 22 (11, 32) 22 (11, 32) 22 (11, 32) 22 (11, 32) 22 (11, 32) 22 (11, 32)
n 6 (5, 11) 10 (6, 27) 3 (1, 8) 1 (0, 4) 5 (2, 10) 5 (2, 10) 1 (0, 3) 2 (0, 6)
post_p 0.36 (0.14, 0.49) 0.36 (0.17, 0.46) 0.37 (0.21, 0.45) 0.35 (0.16, 0.43) 0.35 (0.19, 0.47) 0.37 (0.23, 0.49) 0.31 (0.24, 0.44) 0.32 (0.23, 0.47)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.148 (0.103, 0.218) 0.146 (0.112, 0.181) 0.189 (0.125, 0.733) 0.298 (0.151, 3.27) 0.161 (0.105, 0.32) 0.15 (0.097, 0.218) 0.299 (0.093, 0.925) 0.193 (0.102, 0.365)
Carboplatin count 17 17 17 17 17 17 17 17
time 20 (13, 33) 20 (13, 33) 20 (13, 33) 20 (13, 33) 20 (13, 33) 20 (13, 33) 20 (13, 33) 20 (13, 33)
n 4 (2, 8) 8 (2, 15) 5 (3, 8) 3 (1, 6) 3 (1, 9) 3 (1, 10) 3 (1, 6) 4 (3, 7)
post_p 0.36 (0.19, 0.44) 0.32 (0.14, 0.45) 0.4 (0.2, 0.48) 0.38 (0.2, 0.49) 0.36 (0.27, 0.48) 0.37 (0.24, 0.49) 0.35 (0.19, 0.46) 0.37 (0.18, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.182 (0.111, 0.323) 0.175 (0.113, 0.622) 0.161 (0.1, 0.307) 0.151 (0.091, 3.734) 0.173 (0.124, 0.364) 0.162 (0.1, 0.734) 0.172 (0.141, 0.523) 0.168 (0.117, 0.366)
Niraparib count 26 26 26 26 26 26 26 26
time 24 (14, 36) 24 (14, 36) 24 (14, 36) 24 (14, 36) 24 (14, 36) 24 (14, 36) 24 (14, 36) 24 (14, 36)
n 5 (2, 12) 6 (2, 24) 5 (2, 16) 3 (1, 8) 4 (1, 10) 3 (1, 7) 4 (2, 8) 3 (1, 6)
post_p 0.35 (0.21, 0.47) 0.38 (0.19, 0.49) 0.32 (0.17, 0.45) 0.33 (0.19, 0.47) 0.37 (0.21, 0.48) 0.41 (0.24, 0.49) 0.33 (0.19, 0.46) 0.34 (0.18, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.159 (0.116, 0.302) 0.125 (0.109, 0.365) 0.16 (0.117, 0.402) 0.176 (0.1, 0.46) 0.152 (0.087, 1.138) 0.167 (0.105, 0.36) 0.176 (0.113, 0.359) 0.18 (0.129, 0.467)